1-Octadecyne is primarily used in the field of organic synthesis, where it serves as a building block for the creation of more complex molecules. It is often employed in the preparation of long-chain aliphatic compounds, which are useful in the development of surfactants, lubricants, and polymers. Additionally, it is utilized in research involving surface modification and self-assembled monolayers (SAMs) due to its ability to form stable layers on various substrates. In materials science, 1-Octadecyne is used to modify the surface properties of nanoparticles, enhancing their compatibility with different matrices. It also finds applications in the study of carbon-carbon triple bond reactions, contributing to advancements in synthetic chemistry and catalysis.