[(4-Bromobenzyl)oxy](tert-butyl)dimethylsilane
≥98%
Reagent
Code: #88249
CAS Number
87736-74-1
blur_circular Chemical Specifications
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Molecular Information
Weight
301.3 g/mol
Formula
C₁₃H₂₁BrOSi
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Registry Numbers
MDL Number
MFCD07368899
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Physical Properties
Boiling Point
160°C/0.3mmHg(lit.)
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Storage & Handling
Storage
room temperature, dry
description Product Description
This compound is the tert-butyldimethylsilyl (TBDMS) protected form of 4-bromobenzyl alcohol, serving as a key intermediate in organic synthesis. The TBDMS group shields the hydroxyl functionality, preventing interference during reactions involving the 4-bromobenzyl moiety, which acts as a handle for further functionalization, such as palladium-catalyzed cross-coupling due to the bromine substituent. It is particularly useful in the synthesis of pharmaceuticals, natural products, and other complex molecules, where selective manipulation of functional groups is essential. The stability of the TBDMS protection across a broad range of conditions ensures reliability in multi-step synthetic sequences.
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