This chemical is primarily used in organic synthesis as a protecting group for alcohols. Its t-butyldiphenylsilyl (TBDPS) group is particularly effective in shielding hydroxyl groups during complex multi-step reactions, ensuring they remain unaffected while other functional groups undergo transformation. This is especially valuable in the synthesis of pharmaceuticals, natural products, and fine chemicals, where selective protection and deprotection are critical. Additionally, it is employed in the preparation of silicon-based materials and as an intermediate in the development of specialty polymers. Its stability under various reaction conditions makes it a versatile tool in advanced chemical research and industrial applications.