5-((Tert-butyldimethylsilyl)oxy)pentan-1-ol is a mono-protected derivative of pentane-1,5-diol, featuring a tert-butyldimethylsilyl (TBDMS) group on the 5-position hydroxyl. This protection strategy allows the free 1-position hydroxyl to undergo selective reactions, such as esterification, etherification, or coupling, while the TBDMS-shielded group remains stable under basic, nucleophilic, or oxidative conditions. It serves as a versatile building block in organic synthesis for assembling polyfunctional molecules, particularly in the total synthesis of natural products, pharmaceuticals, and polymers. Deprotection of the TBDMS group can be achieved mildly with tetrabutylammonium fluoride (TBAF) or acidic conditions to afford the symmetric diol.