Used as a protecting group for alcohols in organic synthesis, particularly in complex molecule construction such as natural product synthesis. The tert-butyl propargyl ether group stabilizes hydroxyl functionalities under a variety of reaction conditions and can be selectively removed when needed. Its robustness under basic and mildly acidic conditions makes it valuable in multi-step syntheses. Additionally, the propargyl moiety allows for further functionalization via click chemistry or metal-catalyzed coupling reactions, enabling modular assembly of advanced intermediates in pharmaceutical and agrochemical research.