SKF 86466 hydrochloride is primarily utilized in pharmacological research as a selective alpha-2 adrenergic receptor antagonist. It is extensively employed in studies aimed at understanding the role of alpha-2 adrenergic receptors in various physiological processes, including neurotransmission, cardiovascular regulation, and metabolic control. Researchers use this compound to block alpha-2 receptors, allowing them to investigate the effects of such inhibition on blood pressure, heart rate, and sympathetic nervous system activity. Additionally, it is applied in experimental models to explore its potential therapeutic implications in conditions like hypertension, anxiety, and depression. Its specificity makes it a valuable tool for dissecting the complex mechanisms of adrenergic signaling pathways.