A2AR-agonist-1 is a selective adenosine A2A receptor (A2AR) agonist primarily used as a research tool in pharmacological and biomedical studies. It activates A2A receptors to investigate signaling pathways involved in inflammation, immune modulation, and neuroprotection. In cancer research, it is employed to model immunosuppressive effects in the tumor microenvironment, where A2A activation suppresses T-cell activity, aiding studies on immunotherapy resistance. For neurodegenerative conditions like Parkinson's disease, it is studied for its potential neuroprotective roles by influencing dopaminergic neuron function and reducing excitotoxicity, though clinical applications often favor antagonists. In cardiovascular research, A2AR-agonist-1 demonstrates protective effects against ischemia-reperfusion injury through vasodilation, improved blood flow, and anti-inflammatory actions.