Used as a silylating agent in organic synthesis, particularly for the protection of hydroxyl, amino, and carboxylic acid functional groups. Its bulky structure enhances selectivity in reactions, making it valuable in the synthesis of complex molecules, including pharmaceuticals and natural products. Commonly employed in peptide chemistry and nucleotide synthesis where controlled silylation is critical. Also finds use in materials science for surface modification of silica-based substrates, improving thermal stability and hydrophobicity. Suitable for applications requiring high steric hindrance and resistance to hydrolysis.