1-(Trifluoroacetyl)imidazole is a versatile specialty chemical reagent widely used in organic synthesis and analytical chemistry. It is particularly effective in the acylation of alcohols, amines, and thiols, enabling the introduction of the trifluoroacetyl group into various molecules for derivatization in gas chromatography (GC) analysis, with purity ≥98.5% suitable for such applications. This compound is also employed in the preparation of trifluoroacetyl-protected intermediates, which are crucial in peptide synthesis and the development of pharmaceuticals. Additionally, it serves as a catalyst or activator in certain chemical reactions, enhancing reaction efficiency and selectivity. Its applications extend to the modification of biomolecules, aiding in the study of biochemical processes and the design of novel therapeutic agents.