Used as an active ester coupling agent in organic synthesis, particularly in peptide and amide bond formation. It enhances coupling efficiency by activating carboxylic acids, making it useful in pharmaceutical synthesis where mild reaction conditions are required. Its iodoaryl group allows for further functionalization via cross-coupling reactions such as Suzuki or Heck reactions, enabling the construction of complex molecules in medicinal chemistry. Commonly employed in bioconjugation and labeling strategies due to its reactivity with primary amines under physiological conditions.