Esomeprazole potassium salt is widely used in the treatment of gastrointestinal disorders, particularly those related to excessive stomach acid production, including Zollinger-Ellison syndrome. It is effective in managing conditions such as gastroesophageal reflux disease (GERD), where it helps alleviate symptoms like heartburn and acid regurgitation by reducing acid secretion in the stomach. Additionally, it is used in the healing of erosive esophagitis, a condition caused by stomach acid damaging the esophagus.

This compound is also employed in combination with antibiotics for the eradication of Helicobacter pylori, a bacterium linked to peptic ulcers. Its ability to maintain a reduced acid environment in the stomach enhances the effectiveness of antibiotic therapy. Furthermore, esomeprazole potassium salt is utilized in the prevention of gastric ulcers in patients who are at risk due to long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs).

Its fast-acting and long-lasting effects make it a preferred choice in both acute and chronic management of acid-related disorders.