Ethyl chlorooxoacetate is primarily used in organic synthesis as a versatile reagent. It serves as a key intermediate in the production of various pharmaceuticals, agrochemicals, and fine chemicals. Its reactive chloro and ester groups make it valuable for introducing oxoacetate moieties into target molecules. In medicinal chemistry, it is employed to synthesize compounds with potential biological activities, such as antimicrobial or antiviral agents. Additionally, it is utilized in the preparation of dyes, pigments, and other specialty chemicals. Its role in cross-coupling reactions and as a building block for complex organic structures further highlights its importance in industrial and research applications.