Used primarily as a reagent in organic synthesis, this compound is highly effective for introducing pentafluorobenzoyl groups into various molecules. It is commonly employed in the preparation of derivatives for analytical purposes, particularly in gas chromatography and mass spectrometry, where it enhances the detectability of compounds due to the electron-withdrawing properties of the pentafluorobenzoyl group. Additionally, it finds application in the development of pharmaceuticals and agrochemicals, where it aids in the modification of molecules to improve their stability, reactivity, or bioavailability. Its use in peptide chemistry is also notable, as it helps in the protection of amino groups during synthesis.