Ramiprilat (Ramipril Diacid)
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Ramiprilat (Ramipril diacid) is the active metabolite of the prodrug Ramipril, a potent angiotensin-converting enzyme (ACE) inhibitor. It is primarily utilized as a reference standard and in pharmaceutical research for studying the treatment of hypertension, heart failure, and cardiovascular complications. By inhibiting ACE, Ramiprilat reduces the formation of angiotensin II, promoting vasodilation, lowering blood pressure, and improving blood flow. This mechanism supports its role in reducing risks of stroke, heart attack, and kidney disease, including renoprotective effects in diabetic nephropathy. It is not typically administered directly due to poor oral bioavailability but is crucial for understanding the therapeutic actions of Ramipril.
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