Perindopril is primarily used in the treatment of high blood pressure (hypertension) and heart failure. It helps to relax blood vessels, allowing blood to flow more smoothly and reducing the workload on the heart. Additionally, it is prescribed to improve survival rates following a heart attack and to prevent strokes in patients with peripheral arterial disease. Its long-acting nature makes it effective for once-daily dosing, providing consistent control over blood pressure levels. It is often combined with other medications, such as diuretics, to enhance its efficacy in managing cardiovascular conditions.