3H-1,2-Benzodithiol-3-one 1,1-Dioxide, known as the Beaucage reagent, is a specialized sulfurizing agent widely used in organic synthesis, particularly for introducing sulfur atoms into molecular structures. It is essential in the solid-phase synthesis of oligonucleotides, enabling the formation of phosphorothioate linkages critical for therapeutic antisense drugs and modified nucleic acids in the pharmaceutical industry. Additionally, it serves as a versatile reagent for preparing thioesters, thioamides, and other sulfur-containing intermediates vital in pharmaceutical, agrochemical, and material science applications, including the development of advanced polymers with tailored properties.