11β-Misoprostol is a synthetic prostaglandin E1 analog primarily used in medical applications. It is indicated for the prevention and treatment of NSAID-induced gastric and duodenal ulcers due to its protective effects on the gastrointestinal mucosa. In obstetrics and gynecology, it induces uterine contractions and promotes cervical ripening, making it essential for managing postpartum hemorrhage—a leading cause of maternal mortality—by facilitating effective uterine contraction. It is also widely utilized in medical abortions, either alone or in combination with mifepristone, to safely terminate early pregnancies. Additionally, 11β-Misoprostol treats incomplete or missed miscarriages by aiding the expulsion of retained uterine tissue. Its role extends to pre-procedure cervical softening in gynecological surgeries, reducing procedural complications and improving patient outcomes. Due to its stability, efficacy, and versatility, it is a valuable therapeutic agent in both gastrointestinal and reproductive health, always requiring medical supervision.