Used in cancer research, particularly in studying signaling pathways involving HER receptors (such as HER2 and HER3) that play key roles in tumor growth and progression. Serves as a recombinant ligand to activate NRG1-dependent cellular responses in vitro and in vivo. Applied in cell culture studies to investigate cell proliferation, differentiation, and survival in breast, ovarian, and other cancers. Also utilized in drug development to evaluate inhibitors targeting the HER signaling network. The His tag facilitates purification and detection in experimental systems.