γ-Mangostin is a natural xanthone derivative primarily studied for its potent biological activities. It exhibits strong anti-inflammatory effects by inhibiting key signaling pathways such as NF-κB and MAPK, making it a candidate for research in chronic inflammatory diseases. It also shows significant antioxidant properties, helping to neutralize free radicals and reduce oxidative stress in cells.

Research explores its potential in cancer therapy due to its ability to induce apoptosis and suppress proliferation in various cancer cell lines, including breast, colon, and liver cancer. Its antimicrobial activity against certain bacteria and fungi supports its traditional use in treating infections.

Additionally, γ-Mangostin has demonstrated neuroprotective effects in preclinical models, suggesting possible application in neurodegenerative conditions like Alzheimer’s disease. It also shows promise in metabolic health, with studies indicating it may help regulate glucose uptake and lipid metabolism.

Most applications remain in the preclinical research stage, with ongoing studies focused on improving bioavailability and evaluating long-term safety.