Cytosine β-D-arabinofuranoside hydrochloride
10mM in DMSO
Reagent
Code: #157894
CAS Number
69-74-9
blur_circular Chemical Specifications
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Molecular Information
Weight
279.68 g/mol
Formula
C₉H₁₃N₃O₅·HCl
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Registry Numbers
MDL Number
MFCD00012839
thermostat
Physical Properties
Melting Point
197-198 °C(lit.)
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Storage & Handling
Storage
-20°C
description Product Description
Used primarily in the treatment of acute myeloid leukemia and other hematologic cancers, this compound acts as a nucleoside analog that interferes with DNA synthesis. It is incorporated into DNA during the S phase of cell division, leading to chain termination and inhibition of DNA polymerase, which ultimately triggers apoptosis in rapidly dividing cancer cells. It is also used in certain viral infections due to its antiviral activity, particularly against herpesviruses. In research, it serves as a tool to synchronize cell cycles and study DNA repair mechanisms. Its ability to cross the blood-brain barrier makes it useful in treating meningeal leukemia.
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