Used as a catalyst in cross-coupling reactions, particularly in the formation of carbon-carbon bonds. It facilitates reactions such as Kumada and Negishi couplings, which are essential in synthesizing complex organic molecules for pharmaceuticals, agrochemicals, and advanced materials. The presence of the dimethoxy-substituted bipyridine ligand enhances stability and electron donation, improving catalytic efficiency and selectivity under mild conditions. Also employed in research for developing nickel-based catalytic systems as a more economical alternative to palladium catalysts.