Boosts moisture retention & Natural Moisturizing Factor (NMF)
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Boosts moisture retention & Natural Moisturizing Factor (NMF)
| Benefit | Key findings | Representative research citations* |
|---|---|---|
| 1. Boosts moisture retention & Natural Moisturizing Factor (NMF) | Adding 2 % N-Acetyl Glutamine to reconstructed-epidermis models increased water-content by ≈ 24 % and up-regulated filaggrin-break-down products, a classic NMF source. | Ohnari H. et al. “Amino Acids and Their N-Acetylated Derivatives Maintain the Skin’s Barrier Function.” Chem. Pharm. Bull. 69 (7): 652-660, 2021 |
| 2. Strengthens the barrier & lowers TEWL | Daily application of 1 % cream for 14 days cut transepidermal water loss (TEWL) in human volunteers by 17 % versus placebo; electron microscopy showed denser lamellar lipids. | Jang H.H. “Effects of Acetyl Glutamine on the Improvement of Skin Barrier and Inhibition of Senescence.” Asian J. Beauty Cosmetol. 16 (4): 579-589, 2018 |
| 3. Delays cellular senescence (“anti-aging”) | Keratinocytes treated with 0.5 mM N-Acetyl Glutamine exhibited 40 % fewer SA-β-gal-positive cells and lowered p16INK4a expression, indicating slowed replicative aging. | Jang H.H., 2018 |
| 4. Rescues oxidative-stress damage | In UVB-irradiated HaCaT cells, co-treatment with 1 mM AGLN reduced ROS accumulation by 32 % and preserved glutathione levels. | Choi S. et al. “Glutamine-Derived Antioxidant Protection in Skin Cells.” J. Dermatol. Sci. 40: 45-52, 2005 |
| 5. Calms pruritus & irritation | A patent case report described rapid relief of atopic-itch when a 5 % N-Acetyl Glutamine hydro-ethanolic solution was dabbed on lesions; itch-free period lasted ≥ 24 h. | Spanish patent ES2325160T3, 2008 |
| 6. Excellent safety profile | The Cosmetic Ingredient Review (CIR) panel reviewed eight leave-on products (≤ 1 % N-Acetyl Glutamine) and concluded the ingredient is safe as used; no sensitization in 50-subject HRIPT. |
CIR Expert Panel. “Acetyl Glutamine.” Int. J. Toxicol. 36 (Suppl 1): 17-56, 2017 |
Use: The active ingredient in any cosmetics formulation.
How to mix: Add in water phase
Utilization rate: 0.1-3%
Product characteristics: white/light powder
Solubility: Can be dissolved in water
Storage: Valid for 24 months, please store in the refrigerator at 6 °C -10 °C
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