Special type of Phytosphingosine that can directly disperse in water.
Contain a minimum of 11.5% of Phytosphingosine
Ceracare™ Phytosphingosine (Water Dispersible Phytosphingosine)
Special type of Phytosphingosine that can directly disperse in water.
Contain a minimum of 11.5% of Phytosphingosine
Evidence-based topical benefits of phytosphingosine (PHS)
| Benefit |
Key mechanistic insight |
Representative evidence |
| Strengthens skin-barrier & boosts hydration |
PHS-based ceramide NP/ENP tightens lamellar lipid packing, raises NMF, and lowers TEWL |
4-week, 20-subject cream study: +26–54 % corneometer hydration and significant TEWL drop with only 0.02–0.05 % CerENP (co-formulated with CerNP). MDPI |
| Anti-inflammatory / atopic-skin relief |
Inhibits NF-κB & MAPK (p38/ERK/JNK) cascades → ↓ NO, PGE₂, IL-6/8, TARC |
RAW264.7 & HaCaT models: PHS 0.5–5 µg mL⁻¹ cut cytokine output and blocked NF-κB nuclear translocation. ResearchGate • 4-week clinical cream with ceramide + PHS reduced dermatitis scores 61 %. PubMed Central |
| Antimicrobial & anti-acne |
Disrupts bacterial membranes of Cutibacterium acnes, S. aureus; calms follicular inflammation |
Split-face pilot: 0.2 % PHS gel ↓ papules/pustules 37 % in 6 weeks; MIC 4–8 µg mL⁻¹ against C. acnes. PubMed • Host-lipid review confirms broad Gram ± activity. PubMed Central |
| Accelerates re-epithelialisation |
Phytosphingosine-1-phosphate (PhS1P) synergises with EGF → ↑ keratinocyte migration/proliferation |
Scratch-wound assay: PhS1P 1–10 µM + EGF closed gaps ~30 % faster vs. EGF alone. Spandidos Publications |
| Supports epidermal maturation / smoother texture |
Up-regulates filaggrin & involucrin, enhancing corneocyte cohesion |
Molecular endpoints reported alongside barrier-study above. MDPI |
Use: The main ingredient in moisturizer products for sensitive skin, dry skin
How to mix: Disperse in water phase
Utilization rate: 0.1-10% (recommend 5%)
Product characteristics: white/light yellow paste
Solubility: Can be dispersed in water
Storage: Valid for 24 months, please store in the room temp. Do not freeze.
INCI: Water, Propylene glycol, Phytosphingosine, Caprylic/Capric Triglyceride, Polysorbate 80, Phenoxyethanol, Chlorophenesin
