AFBI is primarily used as a highly reactive hypervalent iodine reagent in organic synthesis. It serves as an efficient fluorinating agent, enabling the introduction of fluorine atoms into various organic molecules under mild conditions. This makes it valuable in the development of fluorinated pharmaceuticals and agrochemicals, where precise fluorination can enhance metabolic stability, bioavailability, and binding affinity. AFBI is especially useful for selective C–H fluorination and functionalization of heteroarenes, offering high chemoselectivity and functional group tolerance. Its reactivity allows for rapid construction of complex fluorinated scaffolds, which are increasingly important in medicinal chemistry and drug discovery. Additionally, AFBI has been employed in radical fluorination reactions, expanding its utility in modern synthetic methodologies.