18β-Glycyrrhetinic acid is widely used in the pharmaceutical and cosmetic industries due to its anti-inflammatory, antioxidant, and skin-soothing properties. In skincare, it is incorporated into creams, lotions, and serums to reduce redness, irritation, and signs of aging by inhibiting enzymes that break down collagen and elastin. It also helps in treating conditions like eczema, psoriasis, and acne due to its ability to regulate sebum production and calm inflamed skin.

In medicine, it is utilized for its hepatoprotective effects, aiding in the treatment of liver disorders by reducing oxidative stress and inflammation. It also exhibits gastroprotective properties, contributing to the management of peptic ulcers by inhibiting inflammatory pathways. Additionally, it has shown potential in antiviral and anticancer research, where it is studied for its ability to inhibit the growth of certain viruses and tumor cells.