2-((tert-Butyldiphenylsilyl)oxy)-N-methoxy-N-methylacetamide is a specialty chemical intermediate, specifically a protected Weinreb amide derivative of glycolic acid. It is used in organic synthesis to introduce alpha-oxygenated carbonyl functionalities. The tert-butyldiphenylsilyl (TBDPS) protecting group shields the hydroxyl moiety, enabling selective manipulation of the Weinreb amide, which reacts with organometallic reagents to form ketones. This compound is valuable in multi-step syntheses of complex molecules, including pharmaceuticals and natural products, due to its stability and orthogonality in deprotection strategies.