N-[4-(4-Fluorophenyl)-6-(1-methylethyl)-5-[(1E)-2-[(2S,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethenyl]-2-pyrimidinyl]-N-methylmethanesulfonamide

98%

Reagent Code: #218707
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CAS Number 503610-43-3

science Other reagents with same CAS 503610-43-3

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 463.52 g/mol
Formula C₂₂H₂₆FN₃O₅S
thermostat Physical Properties
Melting Point 131℃
Boiling Point 695.0±65.0℃(Predicted)
inventory_2 Storage & Handling
Density 1.387 g/cm3
Storage -20℃

description Product Description

Widely used in the management of hypercholesterolemia, this compound functions as a potent inhibitor of HMG-CoA reductase, a key enzyme in cholesterol biosynthesis. It effectively lowers low-density lipoprotein (LDL) cholesterol and total cholesterol levels in the bloodstream, reducing the risk of cardiovascular diseases such as atherosclerosis, myocardial infarction, and stroke. Its high bioavailability and long half-life allow for once-daily dosing, improving patient compliance. The compound is particularly effective in patients who do not achieve target cholesterol levels through diet and lifestyle changes alone. It is also used in combination with other lipid-lowering agents for enhanced therapeutic effect. Due to its impact on lipid metabolism, it plays a critical role in both primary and secondary prevention of coronary heart disease.

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Size Availability Unit Price Quantity
inventory 5mg
10-20 days ฿8,340.00
inventory 50mg
10-20 days ฿22,120.00

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N-[4-(4-Fluorophenyl)-6-(1-methylethyl)-5-[(1E)-2-[(2S,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethenyl]-2-pyrimidinyl]-N-methylmethanesulfonamide
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Widely used in the management of hypercholesterolemia, this compound functions as a potent inhibitor of HMG-CoA reductase, a key enzyme in cholesterol biosynthesis. It effectively lowers low-density lipoprotein (LDL) cholesterol and total cholesterol levels in the bloodstream, reducing the risk of cardiovascular diseases such as atherosclerosis, myocardial infarction, and stroke. Its high bioavailability and long half-life allow for once-daily dosing, improving patient compliance. The compound is particularly effective in patients who do not achieve target cholesterol levels through diet and lifestyle changes alone. It is also used in combination with other lipid-lowering agents for enhanced therapeutic effect. Due to its impact on lipid metabolism, it plays a critical role in both primary and secondary prevention of coronary heart disease.
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