Used in organic synthesis as a building block for pharmaceuticals and agrochemicals, particularly in Sonogashira coupling reactions to form conjugated enynes. Its aldehyde group allows further functionalization, such as condensation reactions to produce Schiff bases or reduction to alcohols. The trimethylsilyl-protected acetylene offers stability during reactions and can be deprotected to yield terminal alkynes for click chemistry or metal-catalyzed couplings. Commonly applied in the development of bioactive molecules and functional materials.